Answer: What Microsoft Office program is best for making an infographic?

PowerPoint could serve this purpose nicely.

You’re able to change the size of the slide, and output it as any number of formats (image or pdf, for instance).

In the most recent versions Microsoft has done a lot to improve the way it works with images (alignment, cropping, effects), as well as design assistance like alignment, spacing etc., making it easier to get your desired layout.